Yesterday's post about Norton Identity Safe, the surprisingly good free password manager, got me thinking about other great freeware - the utilities I use daily and, frankly, couldn't live without. Cancer 47, 1231–1243 (2011).I used PhraseExpress to insert the image credit below. Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: activation of MET as one mechanism for drug resistance.
Utilities by mouse plus#
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. Stromal disrupting effects of nab-paclitaxel in pancreatic cancer. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. A model for personalized in vivo analysis of human immune responsiveness. Preclinical testing of antileukemic drugs using an in vivo model of systemic disease. Lurbinectedin (PM01183), a new DNA minor groove binder, inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Organoid cultures derived from patients with advanced prostate cancer. Organoid models of human and mouse ductal pancreatic cancer. Comparative profiling of the novel epothilone, sagopilone, in xenografts derived from primary non-small cell lung cancer. Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study. Patient-derived models of acquired resistance can identify effective drug combinations for cancer. Integrated next generation sequencing and ¨avatar¨ mouse models for personalized cancer treatment. Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft. A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer. Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development. Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer. A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma. Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers. A new model of patient tumor-derived breast cancer xenografts for preclinical assays. A molecularly annotated platform of patient-derived xenografts (“xenopatients”) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Practices and pitfalls of mouse cancer models in drug discovery. Transcriptional dissection of pancreatic tumors engrafted in mice.
Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer. Molecular profiling of patient-derived breast cancer xenografts. Patient-derived xenograft models: an emerging platform for translational cancer research. Genome remodelling in a basal-like breast cancer metastasis and xenograft. P圜lone: statistical inference of clonal population structure in cancer. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma. A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models. Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes.
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